Breckinridge Elkins rides into town from a cow camp with money to buy supplies but gets sidetracked by a bizarre patent medicine salesman and his musical sidekick. He meets a young man who claims Breck’s friend Bearfield Buckner has gone mad, obsessed with marrying a woman. Breck gives the young man the supply money and rides to another town—without a railroad—taking the salesman and his companion along. He finds Bearfield drunk and belligerent, subdues him in a fierce fight, and hauls him to a cabin to administer the “loco-cure.” However, both the wagon and a horse are stolen by the companions. Breckinridge ties up Bearfield and sends him by train to Santa Fe. Back in town, the ranch owner and cowboys wrongly accuse Breck of gambling away the supply money. A fight ensues, and it’s revealed that Bearfield was not crazy—his girl and the young man had run off with both Breck’s money and Bearfield’s bride. Just then, a telegram arrives: Bearfield has taken over the train and is forcing it to return. With the situation out of control, Breckinridge flees for Old Mexico.